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Uses of retrosynthesis

This is the second part of my coverage of the two recently published syntheses of (–)-maoecrystal V, dealing with the route completed jointly by the Davies and Zakarian s (Part 1, featuring the Thomson synthesis is here). The modules will consolidate your existing knowledge and provide a base upon which you can develop advanced chemistry concepts. Also somewhat unusually, the two US-based s involved in the collaboration are both headed up by professors who orinally hail from outside the States.[1] Sharp eyed readers will note that a large part of this synthesis is adapted from the Zakarian 's previously reported total synthesis of racemic maoecrystal V from back in 2013, and in fact it reuses the same intramolecular Diels–Alder key step to construct the fused furanobicyclo[2.2.2]octane ring system: This well-planned cycloaddition enabled the execution of a concise and efficient diastereoselective route (24 steps @ 1.5% overall yield) that compared quite favorably with the others that had been reported at the time.

Uses of retrosynthesis

Uses of retrosynthesis

It explores the different sources of medicine, how they work and how they can be formulated (eg tablet, cream, inhaler), analysed and tested. If you enjoy mainstream chemistry and would like to apply the knowledge and ss you gain to industry, research or teaching, Kingston University's Chemistry degree is ideal.

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    Uses of retrosynthesis

    Uses of retrosynthesis

    Uses of retrosynthesis

    Pharmaceutical science is concerned with the desn and development of new drugs for clinical purposes. The basis for and principles of retrosynthetic analyses are thorougy presented and discussed and subsequently applied to work out synthetic strategies for complex organic molecules.

    Uses of retrosynthesis

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